INVEGA SUSTENNA vs LURASIDONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. INVEGA SUSTENNA and LURASIDONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INVEGA SUSTENNA	LURASIDONE HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	—	~$9.42 /30
Type	RX	RX
Active ingredient	PALIPERIDONE PALMITATE	LURASIDONE HYDROCHLORIDE
Manufacturer	Janssen Pharms	Chartwell Rx
Dosage forms	Injectable	Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 18 hours (mean, %CV 7), measured after a 40 mg oral dose in adults
Treats	Bipolar Disorder, Depressive Disorder, Schizophrenia	Bipolar Disorder, Major Depressive Disorder, Schizophrenia

invega sustenna lurasidone hydrochloride

Rating

70/100

New

Pharmacy pays

—

~$9.42 /30

Type

Active ingredient

PALIPERIDONE PALMITATE

LURASIDONE HYDROCHLORIDE

Manufacturer

Janssen Pharms

Chartwell Rx

Dosage forms

Injectable

Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

—

about 18 hours (mean, %CV 7), measured after a 40 mg oral dose in adults

Treats

Bipolar Disorder, Depressive Disorder, Schizophrenia

Bipolar Disorder, Major Depressive Disorder, Schizophrenia

Frequently asked questions

What is the difference between Invega Sustenna and Lurasidone Hydrochloride?

Invega Sustenna contains Paliperidone Palmitate, while Lurasidone Hydrochloride contains Lurasidone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.