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INSPRA vs SPIRONOLACTONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. INSPRA and SPIRONOLACTONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

~$10.55 /30
~$2.68 /30

Type

RX
RX

Active ingredient

EPLERENONE
SPIRONOLACTONE

Dosage forms

Tablet
Suspension, Tablet

Drug class

Aldosterone Antagonist
Aldosterone Antagonist

Boxed warning

None
None

Half-life

about 1.4 hours

Treats

Hypertension, Systolic Heart Failure
Ascites, Edema, Heart Failure

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Frequently asked questions

Which is cheaper, Inspra or Spironolactone?

Spironolactone costs pharmacies less to acquire — about $2.68 vs $10.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Inspra and Spironolactone?

Inspra contains Eplerenone, while Spironolactone contains Spironolactone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.