IMODIUM vs OPANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. IMODIUM and OPANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	IMODIUM	OPANA
Rating	New	72/100
Pharmacy pays	$0.05 /mL	~$36.74 /30
Type	RX	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	J and J Consumer Inc	Endo Pharms
Dosage forms	Capsule, Solution	Tablet, Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	—
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Pain

imodium opana

Rating

New

72/100

Pharmacy pays

$0.05 /mL

~$36.74 /30

Type

Active ingredient

LOPERAMIDE HYDROCHLORIDE

OXYMORPHONE HYDROCHLORIDE

Manufacturer

J and J Consumer Inc

Endo Pharms

Dosage forms

Capsule, Solution

Tablet, Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

—

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Pain

Frequently asked questions

What is the difference between Imodium and Opana?

Imodium contains Loperamide Hydrochloride, while Opana contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.