IMODIUM vs METHADONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. IMODIUM and METHADONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	IMODIUM	METHADONE HYDROCHLORIDE
Rating	New	72/100
Pharmacy pays	$0.05 /mL	$0.18 /mL
Type	RX	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	METHADONE HYDROCHLORIDE
Manufacturer	J and J Consumer Inc	Hikma
Dosage forms	Capsule, Solution	Injectable, Solution, Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	about 8 to 59 hours (terminal/elimination half-life; a very wide range)
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Opioid-Related Disorders, Intractable Pain

imodium methadone hydrochloride

Rating

New

72/100

Pharmacy pays

$0.05 /mL

$0.18 /mL

Type

Active ingredient

LOPERAMIDE HYDROCHLORIDE

METHADONE HYDROCHLORIDE

Manufacturer

J and J Consumer Inc

Hikma

Dosage forms

Capsule, Solution

Injectable, Solution, Tablet

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is cheaper, Imodium or Methadone Hydrochloride?

Imodium costs pharmacies less to acquire — about $0.05 vs $0.18 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Imodium and Methadone Hydrochloride?

Imodium contains Loperamide Hydrochloride, while Methadone Hydrochloride contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.