IMODIUM A-D vs XERMELO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	IMODIUM A-D	XERMELO
Rating	70/100	New
Pharmacy pays	$0.05 /mL	—
Type	OTC	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	TELOTRISTAT ETIPRATE
Manufacturer	Kenvue Brands	Tersera
Dosage forms	Capsule, Solution, Tablet	Tablet
Drug class	Opioid Agonist	—
Boxed warning	None	None
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	—
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Diarrhea, Malignant Carcinoid Syndrome

imodium a-d xermelo

Rating

70/100

New

Pharmacy pays

$0.05 /mL

—

Type

OTC

Active ingredient

LOPERAMIDE HYDROCHLORIDE

TELOTRISTAT ETIPRATE

Manufacturer

Kenvue Brands

Tersera

Dosage forms

Capsule, Solution, Tablet

Tablet

Drug class

Opioid Agonist

—

Boxed warning

None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

—

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Diarrhea, Malignant Carcinoid Syndrome

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Frequently asked questions

What is the difference between Imodium A-D and Xermelo?

Imodium A-D contains Loperamide Hydrochloride, while Xermelo contains Telotristat Etiprate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.