IMODIUM A-D vs OPANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Attribute	IMODIUM A-D	OPANA
Rating	70/100	72/100
Pharmacy pays	$0.05 /mL	~$36.74 /30
Type	OTC	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Kenvue Brands	Endo Pharms
Dosage forms	Capsule, Solution, Tablet	Tablet, Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	—
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Pain

imodium a-d opana

Rating

70/100

72/100

Pharmacy pays

$0.05 /mL

~$36.74 /30

Type

OTC

Active ingredient

LOPERAMIDE HYDROCHLORIDE

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Kenvue Brands

Endo Pharms

Dosage forms

Capsule, Solution, Tablet

Tablet, Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

—

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Pain

Get imodium a-d

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Frequently asked questions

Which is better-rated, Imodium A-D or Opana?

By our independent rating, Opana scores higher — 3.6 vs 3.5 out of 5 for Imodium A-D. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Imodium A-D and Opana?

Imodium A-D contains Loperamide Hydrochloride, while Opana contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.