IMODIUM A-D vs NUCYNTA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	IMODIUM A-D	NUCYNTA ER
Rating	70/100	New
Pharmacy pays	$0.05 /mL	~$335.93 /30
Type	OTC	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	TAPENTADOL HYDROCHLORIDE
Manufacturer	Kenvue Brands	Collegium Pharm Inc
Dosage forms	Capsule, Solution, Tablet	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Pain

imodium a-d nucynta er

Rating

70/100

New

Pharmacy pays

$0.05 /mL

~$335.93 /30

Type

OTC

Active ingredient

LOPERAMIDE HYDROCHLORIDE

TAPENTADOL HYDROCHLORIDE

Manufacturer

Kenvue Brands

Collegium Pharm Inc

Dosage forms

Capsule, Solution, Tablet

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Pain

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Frequently asked questions

What is the difference between Imodium A-D and Nucynta ER?

Imodium A-D contains Loperamide Hydrochloride, while Nucynta ER contains Tapentadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.