IMODIUM A-D vs LOPERAMIDE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Attribute	IMODIUM A-D	LOPERAMIDE HYDROCHLORIDE
Rating	70/100	70/100
Pharmacy pays	$0.05 /mL	$0.05 /mL
Type	OTC	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	LOPERAMIDE HYDROCHLORIDE
Manufacturer	Kenvue Brands	Jubilant Cadista
Dosage forms	Capsule, Solution, Tablet	Capsule
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	about 10.8 hours (range 9.1 to 14.4 hours)
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

imodium a-d loperamide hydrochloride

Rating

70/100

Pharmacy pays

$0.05 /mL

Type

OTC

Active ingredient

LOPERAMIDE HYDROCHLORIDE

Manufacturer

Kenvue Brands

Jubilant Cadista

Dosage forms

Capsule, Solution, Tablet

Capsule

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Get imodium a-dhigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

Which is better-rated, Imodium A-D or Loperamide Hydrochloride?

Imodium A-D and Loperamide Hydrochloride are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Imodium A-D or Loperamide Hydrochloride?

Pharmacies pay about the same to acquire either one — roughly $0.05 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Imodium A-D and Loperamide Hydrochloride?

Both Imodium A-D and Loperamide Hydrochloride share the active ingredient Loperamide Hydrochloride, but Imodium A-D is sold as OTC and Loperamide Hydrochloride as RX.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.