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IMODIUM A-D EZ CHEWS vs SUBLIMAZE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. IMODIUM A-D EZ CHEWS and SUBLIMAZE PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
72/100

Pharmacy pays

$0.05 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

LOPERAMIDE HYDROCHLORIDE
FENTANYL CITRATE

Dosage forms

Tablet, chewable
Injectable

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery
Pain

Frequently asked questions

Which is cheaper, Imodium A-D Ez Chews or Sublimaze Preservative Free?

Imodium A-D Ez Chews costs pharmacies less to acquire — about $0.05 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Imodium A-D Ez Chews and Sublimaze Preservative Free?

Imodium A-D Ez Chews contains Loperamide Hydrochloride, while Sublimaze Preservative Free contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.