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IMIPRAMINE HYDROCHLORIDE vs SINEQUAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. IMIPRAMINE HYDROCHLORIDE and SINEQUAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
64/100

Pharmacy pays

~$2.54 /30
~$4.84 /30

Type

RX
RX

Active ingredient

IMIPRAMINE HYDROCHLORIDE
DOXEPIN HYDROCHLORIDE

Dosage forms

Tablet
Capsule

Drug class

Tricyclic Antidepressant
Tricyclic Antidepressant

Boxed warning

Half-life

about 8 to 24 hours (average about 17 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis
Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

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Frequently asked questions

Which is better-rated, Imipramine Hydrochloride or Sinequan?

By our independent rating, Imipramine Hydrochloride scores higher — 3.5 vs 3.2 out of 5 for Sinequan. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Imipramine Hydrochloride or Sinequan?

Imipramine Hydrochloride costs pharmacies less to acquire — about $2.54 vs $4.84 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Imipramine Hydrochloride and Sinequan?

Imipramine Hydrochloride contains Imipramine Hydrochloride, while Sinequan contains Doxepin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.