IMIPRAMINE HYDROCHLORIDE vs SERZONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. IMIPRAMINE HYDROCHLORIDE and SERZONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	IMIPRAMINE HYDROCHLORIDE	SERZONE
Rating	72/100	72/100
Pharmacy pays	~$2.59 /30	~$39.92 /30
Type	RX	RX
Active ingredient	IMIPRAMINE HYDROCHLORIDE	NEFAZODONE HYDROCHLORIDE
Manufacturer	Strides Pharma Intl	Bristol Myers Squibb
Dosage forms	Tablet	Tablet
Drug class	Tricyclic Antidepressant	—
Boxed warning	Boxed warning	None
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis	Depressive Disorder, Post-Traumatic Stress Disorders

imipramine hydrochloride serzone

Rating

72/100

Pharmacy pays

~$2.59 /30

~$39.92 /30

Type

Active ingredient

IMIPRAMINE HYDROCHLORIDE

NEFAZODONE HYDROCHLORIDE

Manufacturer

Strides Pharma Intl

Bristol Myers Squibb

Dosage forms

Tablet

Drug class

Tricyclic Antidepressant

—

Boxed warning

None

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

Depressive Disorder, Post-Traumatic Stress Disorders

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Frequently asked questions

Which is better-rated, Imipramine Hydrochloride or Serzone?

Imipramine Hydrochloride and Serzone are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Imipramine Hydrochloride or Serzone?

Imipramine Hydrochloride costs pharmacies less to acquire — about $2.59 vs $39.92 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Imipramine Hydrochloride and Serzone?

Imipramine Hydrochloride contains Imipramine Hydrochloride, while Serzone contains Nefazodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.