IBSRELA vs LINZESS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. IBSRELA and LINZESS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	IBSRELA	LINZESS
Rating	New	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	TENAPANOR HYDROCHLORIDE	LINACLOTIDE
Manufacturer	Ardelyx Inc	Abbvie
Dosage forms	Tablet	Capsule
Drug class	—	Guanylate Cyclase-C Agonist
Boxed warning	Boxed warning	Boxed warning
Treats	Irritable Bowel Syndrome	Constipation, Irritable Bowel Syndrome

ibsrela linzess

Rating

New

70/100

Pharmacy pays

—

Type

Active ingredient

TENAPANOR HYDROCHLORIDE

LINACLOTIDE

Manufacturer

Ardelyx Inc

Abbvie

Dosage forms

Tablet

Capsule

Drug class

—

Guanylate Cyclase-C Agonist

Boxed warning

Treats

Irritable Bowel Syndrome

Constipation, Irritable Bowel Syndrome

Frequently asked questions

What is the difference between Ibsrela and Linzess?

Ibsrela contains Tenapanor Hydrochloride, while Linzess contains Linaclotide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.