HYGROTON vs METOLAZONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. HYGROTON and METOLAZONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYGROTON	METOLAZONE
Rating	70/100	72/100
Pharmacy pays	~$2.67 /30	~$8.76 /30
Type	RX	RX
Active ingredient	CHLORTHALIDONE	METOLAZONE
Manufacturer	Sanofi Aventis US	Unichem
Dosage forms	Tablet	Tablet
Drug class	Thiazide-Like Diuretic	Thiazide-Like Diuretic
Boxed warning	None	None
Half-life	about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)	—
Treats	Edema, Glomerulonephritis, Heart Failure	Edema, Heart Failure, Hypertension

hygroton metolazone

Rating

70/100

72/100

Pharmacy pays

~$2.67 /30

~$8.76 /30

Type

Active ingredient

CHLORTHALIDONE

METOLAZONE

Manufacturer

Sanofi Aventis US

Unichem

Dosage forms

Tablet

Drug class

Thiazide-Like Diuretic

Boxed warning

None

Half-life

about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)

—

Treats

Edema, Glomerulonephritis, Heart Failure

Edema, Heart Failure, Hypertension

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Frequently asked questions

Which is better-rated, Hygroton or Metolazone?

By our independent rating, Metolazone scores higher — 3.6 vs 3.5 out of 5 for Hygroton. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Hygroton or Metolazone?

Hygroton costs pharmacies less to acquire — about $2.67 vs $8.76 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Hygroton and Metolazone?

Hygroton contains Chlorthalidone, while Metolazone contains Metolazone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.