HYDROXYZINE HYDROCHLORIDE vs UNISOM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. HYDROXYZINE HYDROCHLORIDE and UNISOM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYDROXYZINE HYDROCHLORIDE	UNISOM
Rating	New	64/100
Pharmacy pays	$0.04 /mL	—
Type	RX	RX
Active ingredient	HYDROXYZINE HYDROCHLORIDE	DOXYLAMINE SUCCINATE
Manufacturer	Pliva	Pfizer
Dosage forms	Injectable, Solution, Syrup, Tablet	Capsule, Tablet
Drug class	Antihistamine	Antihistamine
Boxed warning	None	None
Half-life	about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)	—
Treats	Anxiety Disorders, Nausea, Pruritus	Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

hydroxyzine hydrochloride unisom

Rating

New

64/100

Pharmacy pays

$0.04 /mL

—

Type

Active ingredient

HYDROXYZINE HYDROCHLORIDE

DOXYLAMINE SUCCINATE

Manufacturer

Pliva

Pfizer

Dosage forms

Injectable, Solution, Syrup, Tablet

Capsule, Tablet

Drug class

Antihistamine

Boxed warning

None

Half-life

about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)

—

Treats

Anxiety Disorders, Nausea, Pruritus

Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

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Frequently asked questions

What is the difference between Hydroxyzine Hydrochloride and Unisom?

Hydroxyzine Hydrochloride contains Hydroxyzine Hydrochloride, while Unisom contains Doxylamine Succinate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.