HYDROXYCHLOROQUINE SULFATE vs MEFLOQUINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. HYDROXYCHLOROQUINE SULFATE and MEFLOQUINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYDROXYCHLOROQUINE SULFATE	MEFLOQUINE HYDROCHLORIDE
Rating	New	72/100
Pharmacy pays	~$4.86 /30	~$127.75 /30
Type	RX	RX
Active ingredient	HYDROXYCHLOROQUINE SULFATE	MEFLOQUINE HYDROCHLORIDE
Manufacturer	Alkaloida Zrt	Hikma
Dosage forms	Tablet	Tablet
Drug class	Antimalarial	Antimalarial
Boxed warning	None	None
Half-life	about 40 to 50 days (terminal elimination half-life in whole blood)	—
Treats	Rheumatoid Arthritis, Systemic Lupus Erythematosus, Malaria	Falciparum Malaria, Vivax Malaria

hydroxychloroquine sulfate mefloquine hydrochloride

Rating

New

72/100

Pharmacy pays

~$4.86 /30

~$127.75 /30

Type

Active ingredient

HYDROXYCHLOROQUINE SULFATE

MEFLOQUINE HYDROCHLORIDE

Manufacturer

Alkaloida Zrt

Hikma

Dosage forms

Tablet

Drug class

Antimalarial

Boxed warning

None

Half-life

about 40 to 50 days (terminal elimination half-life in whole blood)

—

Treats

Rheumatoid Arthritis, Systemic Lupus Erythematosus, Malaria

Falciparum Malaria, Vivax Malaria

Frequently asked questions

Which is cheaper, Hydroxychloroquine Sulfate or Mefloquine Hydrochloride?

Hydroxychloroquine Sulfate costs pharmacies less to acquire — about $4.86 vs $127.75 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Hydroxychloroquine Sulfate and Mefloquine Hydrochloride?

Hydroxychloroquine Sulfate contains Hydroxychloroquine Sulfate, while Mefloquine Hydrochloride contains Mefloquine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.