HYDROMORPHONE HYDROCHLORIDE vs OPANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. HYDROMORPHONE HYDROCHLORIDE and OPANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYDROMORPHONE HYDROCHLORIDE	OPANA
Rating	44/100	72/100
Pharmacy pays	$0.57 /mL	~$36.74 /30
Type	RX	RX
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Hospira	Endo Pharms
Dosage forms	Suppository, Tablet	Tablet, Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	—
Treats	Cough, Postoperative Pain	Pain

hydromorphone hydrochloride opana

Rating

44/100

72/100

Pharmacy pays

$0.57 /mL

~$36.74 /30

Type

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Hospira

Endo Pharms

Dosage forms

Suppository, Tablet

Tablet, Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

—

Treats

Cough, Postoperative Pain

Pain

Frequently asked questions

Which is better-rated, Hydromorphone Hydrochloride or Opana?

By our independent rating, Opana scores higher — 3.6 vs 2.2 out of 5 for Hydromorphone Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Hydromorphone Hydrochloride and Opana?

Hydromorphone Hydrochloride contains Hydromorphone Hydrochloride, while Opana contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.