HYDROCHLOROTHIAZIDE vs METAHYDRIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. HYDROCHLOROTHIAZIDE and METAHYDRIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYDROCHLOROTHIAZIDE	METAHYDRIN
Rating	72/100	70/100
Pharmacy pays	~$0.91 /30	—
Type	RX	RX
Active ingredient	HYDROCHLOROTHIAZIDE	TRICHLORMETHIAZIDE
Manufacturer	Unichem	Sanofi Aventis US
Dosage forms	Capsule, Tablet	Tablet
Drug class	Thiazide Diuretic	—
Boxed warning	None	None
Half-life	about 6 to 15 hours (the label reports a range, not a single number)	—
Treats	Edema, Heart Failure, Hypertension	Edema, Heart Failure, Hypertension

hydrochlorothiazide metahydrin

Rating

72/100

70/100

Pharmacy pays

~$0.91 /30

—

Type

Active ingredient

HYDROCHLOROTHIAZIDE

TRICHLORMETHIAZIDE

Manufacturer

Unichem

Sanofi Aventis US

Dosage forms

Capsule, Tablet

Tablet

Drug class

Thiazide Diuretic

—

Boxed warning

None

Half-life

about 6 to 15 hours (the label reports a range, not a single number)

—

Treats

Edema, Heart Failure, Hypertension

Get hydrochlorothiazidehigher-rated option

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Frequently asked questions

Which is better-rated, Hydrochlorothiazide or Metahydrin?

By our independent rating, Hydrochlorothiazide scores higher — 3.6 vs 3.5 out of 5 for Metahydrin. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Hydrochlorothiazide and Metahydrin?

Hydrochlorothiazide contains Hydrochlorothiazide, while Metahydrin contains Trichlormethiazide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.