HYDROCHLOROTHIAZIDE vs ISMOTIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. HYDROCHLOROTHIAZIDE and ISMOTIC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYDROCHLOROTHIAZIDE	ISMOTIC
Rating	72/100	New
Pharmacy pays	~$0.91 /30	—
Type	RX	RX
Active ingredient	HYDROCHLOROTHIAZIDE	ISOSORBIDE
Manufacturer	Unichem	Alcon
Dosage forms	Capsule, Tablet	Solution
Drug class	Thiazide Diuretic	—
Boxed warning	None	None
Half-life	about 6 to 15 hours (the label reports a range, not a single number)	—
Treats	Edema, Heart Failure, Hypertension	Angina Pectoris, Coronary Disease, Cyanosis

hydrochlorothiazide ismotic

Rating

72/100

New

Pharmacy pays

~$0.91 /30

—

Type

Active ingredient

HYDROCHLOROTHIAZIDE

ISOSORBIDE

Manufacturer

Unichem

Alcon

Dosage forms

Capsule, Tablet

Solution

Drug class

Thiazide Diuretic

—

Boxed warning

None

Half-life

about 6 to 15 hours (the label reports a range, not a single number)

—

Treats

Edema, Heart Failure, Hypertension

Angina Pectoris, Coronary Disease, Cyanosis

Get hydrochlorothiazidehigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Frequently asked questions

What is the difference between Hydrochlorothiazide and Ismotic?

Hydrochlorothiazide contains Hydrochlorothiazide, while Ismotic contains Isosorbide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.