HYCOFENIX vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. HYCOFENIX and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYCOFENIX	RETIN-A
Rating	New	74/100
Pharmacy pays	$0.07 /mL	$1.05 /g
Type	RX	RX
Active ingredient	GUAIFENESIN AND HYDROCODONE BITARTRATE AND PSEUDOEPHEDRINE HYDROCHLORIDE	TRETINOIN
Manufacturer	Chartwell Rx	Valeant Pharm Intl
Dosage forms	Solution	Topical
Drug class	—	Retinoid
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—
Treats	—	Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

hycofenix retin-a

Rating

New

74/100

Pharmacy pays

$0.07 /mL

$1.05 /g

Type

Active ingredient

GUAIFENESIN AND HYDROCODONE BITARTRATE AND PSEUDOEPHEDRINE HYDROCHLORIDE

TRETINOIN

Manufacturer

Chartwell Rx

Valeant Pharm Intl

Dosage forms

Solution

Topical

Drug class

—

Retinoid

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

—

Treats

—

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

What is the difference between Hycofenix and Retin-A?

Hycofenix contains Guaifenesin and Hydrocodone Bitartrate and Pseudoephedrine Hydrochloride, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.