HISTAFED vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. HISTAFED and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HISTAFED	MYSOLINE
Rating	New	74/100
Pharmacy pays	~$8.29 /30	~$2.89 /30
Type	RX	RX
Active ingredient	PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE	PRIMIDONE
Manufacturer	Cenci	Valeant Pharm Intl
Dosage forms	Syrup	Tablet
Drug class	—	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—
Treats	—	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

histafed mysoline

Rating

New

74/100

Pharmacy pays

~$8.29 /30

~$2.89 /30

Type

Active ingredient

PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE

PRIMIDONE

Manufacturer

Cenci

Valeant Pharm Intl

Dosage forms

Syrup

Tablet

Drug class

—

Anti-Epileptic Agent

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

—

Treats

—

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is cheaper, Histafed or Mysoline?

Mysoline costs pharmacies less to acquire — about $2.89 vs $8.29 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Histafed and Mysoline?

Histafed contains Pseudoephedrine Hydrochloride and Triprolidine Hydrochloride, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.