HETLIOZ vs ROZEREM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. HETLIOZ and ROZEREM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HETLIOZ	ROZEREM
Rating	New	New
Pharmacy pays	~$11350.80 /30	~$21.45 /30
Type	RX	RX
Active ingredient	TASIMELTEON	RAMELTEON
Manufacturer	Vanda Pharms Inc	Takeda Pharms USA
Dosage forms	Capsule	Tablet
Drug class	Melatonin Receptor Agonist	Melatonin Receptor Agonist
Boxed warning	None	None
Treats	Circadian Rhythm Sleep Disorders	Sleep Initiation and Maintenance Disorders

hetlioz rozerem

Rating

New

Pharmacy pays

~$11350.80 /30

~$21.45 /30

Type

Active ingredient

TASIMELTEON

RAMELTEON

Manufacturer

Vanda Pharms Inc

Takeda Pharms USA

Dosage forms

Capsule

Tablet

Drug class

Melatonin Receptor Agonist

Boxed warning

None

Treats

Circadian Rhythm Sleep Disorders

Sleep Initiation and Maintenance Disorders

Frequently asked questions

Which is cheaper, Hetlioz or Rozerem?

Rozerem costs pharmacies less to acquire — about $21.45 vs $11350.80 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Hetlioz and Rozerem?

Hetlioz contains Tasimelteon, while Rozerem contains Ramelteon — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.