HEPZATO vs LOMUSTINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. HEPZATO and LOMUSTINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HEPZATO	LOMUSTINE
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	MELPHALAN HYDROCHLORIDE	LOMUSTINE
Manufacturer	Delcath Systems Inc	Carnegie
Dosage forms	Kit	Capsule
Drug class	Alkylating Drug	Alkylating Drug
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 16 to 48 hours — but note this is the half-life of lomustine's metabolites, not the parent drug
Treats	Breast Neoplasms, Multiple Myeloma, Neuroblastoma	Brain Neoplasms, Colonic Neoplasms, Hodgkin Disease

hepzato lomustine

Rating

New

Pharmacy pays

—

Type

Active ingredient

MELPHALAN HYDROCHLORIDE

LOMUSTINE

Manufacturer

Delcath Systems Inc

Carnegie

Dosage forms

Kit

Capsule

Drug class

Alkylating Drug

Boxed warning

Half-life

—

about 16 to 48 hours — but note this is the half-life of lomustine's metabolites, not the parent drug

Treats

Breast Neoplasms, Multiple Myeloma, Neuroblastoma

Brain Neoplasms, Colonic Neoplasms, Hodgkin Disease

Frequently asked questions

What is the difference between Hepzato and Lomustine?

Hepzato contains Melphalan Hydrochloride, while Lomustine contains Lomustine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.