GYNE-LOTRIMIN COMBINATION PACK vs TOLSURA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. GYNE-LOTRIMIN COMBINATION PACK and TOLSURA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GYNE-LOTRIMIN COMBINATION PACK	TOLSURA
Rating	68/100	70/100
Pharmacy pays	$0.21 /mL	$0.84 /mL
Type	RX	RX
Active ingredient	CLOTRIMAZOLE	ITRACONAZOLE
Manufacturer	Bayer Pharms	Mayne Pharma
Dosage forms	Topical, Tablet	Capsule
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	Boxed warning
Half-life	—	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.
Treats	Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

gyne-lotrimin combination pack tolsura

Rating

68/100

70/100

Pharmacy pays

$0.21 /mL

$0.84 /mL

Type

Active ingredient

CLOTRIMAZOLE

ITRACONAZOLE

Manufacturer

Bayer Pharms

Mayne Pharma

Dosage forms

Topical, Tablet

Capsule

Drug class

Azole Antifungal

Boxed warning

None

Boxed warning

Half-life

—

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

Treats

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

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Frequently asked questions

Which is better-rated, Gyne-Lotrimin Combination Pack or Tolsura?

By our independent rating, Tolsura scores higher — 3.5 vs 3.4 out of 5 for Gyne-Lotrimin Combination Pack. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Gyne-Lotrimin Combination Pack or Tolsura?

Gyne-Lotrimin Combination Pack costs pharmacies less to acquire — about $0.21 vs $0.84 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Gyne-Lotrimin Combination Pack and Tolsura?

Gyne-Lotrimin Combination Pack contains Clotrimazole, while Tolsura contains Itraconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.