GYNE-LOTRIMIN 3 vs LOTRIMIN AF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Attribute	GYNE-LOTRIMIN 3	LOTRIMIN AF
Rating	68/100	New
Pharmacy pays	$0.21 /mL	$0.21 /mL
Type	RX	OTC
Active ingredient	CLOTRIMAZOLE	CLOTRIMAZOLE
Manufacturer	Bayer Pharms	Schering Plough
Dosage forms	Topical, Tablet	Spray/Inhaler
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	None
Treats	Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis	Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

gyne-lotrimin 3 lotrimin af

Rating

68/100

New

Pharmacy pays

$0.21 /mL

Type

OTC

Active ingredient

CLOTRIMAZOLE

Manufacturer

Bayer Pharms

Schering Plough

Dosage forms

Topical, Tablet

Spray/Inhaler

Drug class

Azole Antifungal

Boxed warning

None

Treats

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

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Frequently asked questions

Which is cheaper, Gyne-Lotrimin 3 or Lotrimin Af?

Pharmacies pay about the same to acquire either one — roughly $0.21 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Gyne-Lotrimin 3 and Lotrimin Af?

Both Gyne-Lotrimin 3 and Lotrimin Af share the active ingredient Clotrimazole, but Gyne-Lotrimin 3 is sold as RX and Lotrimin Af as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.