GUANFACINE HYDROCHLORIDE vs ONYDA XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. GUANFACINE HYDROCHLORIDE and ONYDA XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GUANFACINE HYDROCHLORIDE	ONYDA XR
Rating	72/100	72/100
Pharmacy pays	~$5.26 /30	~$1.05 /30
Type	RX	RX
Active ingredient	GUANFACINE HYDROCHLORIDE	CLONIDINE HYDROCHLORIDE
Manufacturer	Actavis Elizabeth	Tris Pharma Inc
Dosage forms	Tablet	Suspension, extended release
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	None	None
Half-life	—	about 12 to 16 hours
Treats	Attention Deficit Disorder with Hyperactivity, Hypertension	Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea

guanfacine hydrochloride onyda xr

Rating

72/100

Pharmacy pays

~$5.26 /30

~$1.05 /30

Type

Active ingredient

GUANFACINE HYDROCHLORIDE

CLONIDINE HYDROCHLORIDE

Manufacturer

Actavis Elizabeth

Tris Pharma Inc

Dosage forms

Tablet

Suspension, extended release

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

—

about 12 to 16 hours

Treats

Attention Deficit Disorder with Hyperactivity, Hypertension

Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea

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Frequently asked questions

Which is better-rated, Guanfacine Hydrochloride or Onyda XR?

Guanfacine Hydrochloride and Onyda XR are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Guanfacine Hydrochloride or Onyda XR?

Onyda XR costs pharmacies less to acquire — about $1.05 vs $5.26 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Guanfacine Hydrochloride and Onyda XR?

Guanfacine Hydrochloride contains Guanfacine Hydrochloride, while Onyda XR contains Clonidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.