GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE vs MUCINEX D

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE	MUCINEX D
Rating	72/100	New
Pharmacy pays	$0.07 /mL	$0.07 /mL
Type	RX	OTC
Active ingredient	GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE	GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Granules	Rb Hlth
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

guaifenesin and pseudoephedrine hydrochloride mucinex d

Rating

72/100

New

Pharmacy pays

$0.07 /mL

Type

OTC

Active ingredient

GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Granules

Rb Hlth

Dosage forms

Tablet, extended release

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Get mucinex d

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

Which is cheaper, Guaifenesin and Pseudoephedrine Hydrochloride or Mucinex D?

Pharmacies pay about the same to acquire either one — roughly $0.07 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Guaifenesin and Pseudoephedrine Hydrochloride and Mucinex D?

Both Guaifenesin and Pseudoephedrine Hydrochloride and Mucinex D share the active ingredient Guaifenesin and Pseudoephedrine Hydrochloride, but Guaifenesin and Pseudoephedrine Hydrochloride is sold as RX and Mucinex D as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.