GLUCOPHAGE vs INVOKANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. GLUCOPHAGE and INVOKANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GLUCOPHAGE	INVOKANA
Rating	70/100	72/100
Pharmacy pays	~$0.74 /30	—
Type	RX	RX
Active ingredient	METFORMIN HYDROCHLORIDE	CANAGLIFLOZIN
Manufacturer	Emd Serono	Janssen Pharms
Dosage forms	Tablet	Tablet
Drug class	Biguanide	Sodium-Glucose Cotransporter 2 Inhibitor
Boxed warning	None	None
Half-life	about 6.2 hours (plasma elimination half-life in adults with normal kidney function)	—
Treats	Type 2 Diabetes Mellitus	Type 2 Diabetes Mellitus

glucophage invokana

Rating

70/100

72/100

Pharmacy pays

~$0.74 /30

—

Type

Active ingredient

METFORMIN HYDROCHLORIDE

CANAGLIFLOZIN

Manufacturer

Emd Serono

Janssen Pharms

Dosage forms

Tablet

Drug class

Biguanide

Sodium-Glucose Cotransporter 2 Inhibitor

Boxed warning

None

Half-life

about 6.2 hours (plasma elimination half-life in adults with normal kidney function)

—

Treats

Type 2 Diabetes Mellitus

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Frequently asked questions

Which is better-rated, Glucophage or Invokana?

By our independent rating, Invokana scores higher — 3.6 vs 3.5 out of 5 for Glucophage. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Glucophage and Invokana?

Glucophage contains Metformin Hydrochloride, while Invokana contains Canagliflozin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.