GLUCOPHAGE XR vs TRADJENTA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. GLUCOPHAGE XR and TRADJENTA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GLUCOPHAGE XR	TRADJENTA
Rating	70/100	72/100
Pharmacy pays	~$0.74 /30	—
Type	RX	RX
Active ingredient	METFORMIN HYDROCHLORIDE	LINAGLIPTIN
Manufacturer	Emd Serono	Boehringer Ingelheim
Dosage forms	Tablet, extended release	Tablet
Drug class	Biguanide	Dipeptidyl Peptidase 4 Inhibitor
Boxed warning	None	None
Half-life	about 6.2 hours (plasma elimination half-life in adults with normal kidney function)	about 200 hours — the terminal (elimination) half-life at steady state, per the label
Treats	Type 2 Diabetes Mellitus	Type 2 Diabetes Mellitus

glucophage xr tradjenta

Rating

70/100

72/100

Pharmacy pays

~$0.74 /30

—

Type

Active ingredient

METFORMIN HYDROCHLORIDE

LINAGLIPTIN

Manufacturer

Emd Serono

Boehringer Ingelheim

Dosage forms

Tablet, extended release

Tablet

Drug class

Biguanide

Dipeptidyl Peptidase 4 Inhibitor

Boxed warning

None

Half-life

about 6.2 hours (plasma elimination half-life in adults with normal kidney function)

about 200 hours — the terminal (elimination) half-life at steady state, per the label

Treats

Type 2 Diabetes Mellitus

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Frequently asked questions

Which is better-rated, Glucophage XR or Tradjenta?

By our independent rating, Tradjenta scores higher — 3.6 vs 3.5 out of 5 for Glucophage XR. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Glucophage XR and Tradjenta?

Glucophage XR contains Metformin Hydrochloride, while Tradjenta contains Linagliptin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.