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GLIMEPIRIDE vs GLIPIZIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. GLIMEPIRIDE and GLIPIZIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
66/100

Pharmacy pays

~$1.00 /30
~$1.41 /30

Type

RX
RX

Active ingredient

GLIMEPIRIDE
GLIPIZIDE

Manufacturer

Dosage forms

Tablet
Tablet, Tablet, extended release

Drug class

Sulfonylurea
Sulfonylurea

Boxed warning

None
None

Half-life

about 5 hours (label mean 5.3 hours in adults, ± 4.1 hours — variation between people is wide)
about 2 to 4 hours

Treats

Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus

Get glipizidehigher-rated option

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Frequently asked questions

Which is cheaper, Glimepiride or Glipizide?

Glimepiride costs pharmacies less to acquire — about $1.00 vs $1.41 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Glimepiride and Glipizide?

Glimepiride contains Glimepiride, while Glipizide contains Glipizide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.