GLEEVEC vs RAPAMUNE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. GLEEVEC and RAPAMUNE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GLEEVEC	RAPAMUNE
Rating	70/100	New
Pharmacy pays	~$25.80 /30	~$48.61 /30
Type	RX	RX
Active ingredient	IMATINIB MESYLATE	SIROLIMUS
Manufacturer	Novartis	Pf Prism Cv
Dosage forms	Tablet	Solution
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	Boxed warning
Treats	Lymphoid Leukemia, Myeloid Leukemia, Hypereosinophilic Syndrome	Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms

gleevec rapamune

Rating

70/100

New

Pharmacy pays

~$25.80 /30

~$48.61 /30

Type

Active ingredient

IMATINIB MESYLATE

SIROLIMUS

Manufacturer

Novartis

Pf Prism Cv

Dosage forms

Tablet

Solution

Drug class

Kinase Inhibitor

Boxed warning

None

Boxed warning

Treats

Lymphoid Leukemia, Myeloid Leukemia, Hypereosinophilic Syndrome

Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms

Frequently asked questions

Which is cheaper, Gleevec or Rapamune?

Gleevec costs pharmacies less to acquire — about $25.80 vs $48.61 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Gleevec and Rapamune?

Gleevec contains Imatinib Mesylate, while Rapamune contains Sirolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.