GILOTRIF vs KEYTRUDA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. GILOTRIF and KEYTRUDA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GILOTRIF	KEYTRUDA
Rating	72/100	72/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	AFATINIB DIMALEATE	PEMBROLIZUMAB
Manufacturer	Boehringer Ingelheim	Merck Sharp Dohme
Dosage forms	Tablet	Injectable
Drug class	—	Programmed Death Receptor-1 Blocking Antibody
Boxed warning	None	None
Treats	Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma	Malignant Mesothelioma, Biliary Tract Neoplasms, Urinary Bladder Neoplasms

gilotrif keytruda

Rating

72/100

Pharmacy pays

—

Type

Active ingredient

AFATINIB DIMALEATE

PEMBROLIZUMAB

Manufacturer

Boehringer Ingelheim

Merck Sharp Dohme

Dosage forms

Tablet

Injectable

Drug class

—

Programmed Death Receptor-1 Blocking Antibody

Boxed warning

None

Treats

Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma

Malignant Mesothelioma, Biliary Tract Neoplasms, Urinary Bladder Neoplasms

Frequently asked questions

Which is better-rated, Gilotrif or Keytruda?

Gilotrif and Keytruda are tied at 3.6 out of 5 by our independent rating.

What is the difference between Gilotrif and Keytruda?

Gilotrif contains Afatinib Dimaleate, while Keytruda contains Pembrolizumab — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.