GENGRAF vs SKYRIZI

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. GENGRAF and SKYRIZI are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GENGRAF	SKYRIZI
Rating	72/100	72/100
Pharmacy pays	~$52.85 /30	—
Type	RX	RX
Active ingredient	CYCLOSPORINE	RISANKIZUMAB-RZAA
Manufacturer	Abbvie	Abbvie
Dosage forms	Capsule	Injectable, Solution, Kit
Drug class	Calcineurin Inhibitor Immunosuppressant	—
Boxed warning	Boxed warning	None
Half-life	about 8.4 hours (range 5 to 18 hours)	—
Treats	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus	Psoriasis

gengraf skyrizi

Rating

72/100

Pharmacy pays

~$52.85 /30

—

Type

Active ingredient

CYCLOSPORINE

RISANKIZUMAB-RZAA

Manufacturer

Abbvie

Dosage forms

Capsule

Injectable, Solution, Kit

Drug class

Calcineurin Inhibitor Immunosuppressant

—

Boxed warning

None

Half-life

about 8.4 hours (range 5 to 18 hours)

—

Treats

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Psoriasis

Frequently asked questions

Which is better-rated, Gengraf or Skyrizi?

Gengraf and Skyrizi are tied at 3.6 out of 5 by our independent rating.

What is the difference between Gengraf and Skyrizi?

Gengraf contains Cyclosporine, while Skyrizi contains Risankizumab-Rzaa — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.