GENGRAF vs OTULFI

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. GENGRAF and OTULFI are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GENGRAF	OTULFI
Rating	72/100	68/100
Pharmacy pays	~$52.85 /30	—
Type	RX	RX
Active ingredient	CYCLOSPORINE	USTEKINUMAB-AAUZ
Manufacturer	Abbvie	Fresenius Kabi USA
Dosage forms	Capsule	Injectable, Solution
Drug class	Calcineurin Inhibitor Immunosuppressant	—
Boxed warning	Boxed warning	None
Half-life	about 8.4 hours (range 5 to 18 hours)	—
Treats	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus	Ulcerative Colitis, Crohn Disease, Psoriasis

gengraf otulfi

Rating

72/100

68/100

Pharmacy pays

~$52.85 /30

—

Type

Active ingredient

CYCLOSPORINE

USTEKINUMAB-AAUZ

Manufacturer

Abbvie

Fresenius Kabi USA

Dosage forms

Capsule

Injectable, Solution

Drug class

Calcineurin Inhibitor Immunosuppressant

—

Boxed warning

None

Half-life

about 8.4 hours (range 5 to 18 hours)

—

Treats

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Ulcerative Colitis, Crohn Disease, Psoriasis

Frequently asked questions

Which is better-rated, Gengraf or Otulfi?

By our independent rating, Gengraf scores higher — 3.6 vs 3.4 out of 5 for Otulfi. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Gengraf and Otulfi?

Gengraf contains Cyclosporine, while Otulfi contains Ustekinumab-Aauz — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.