GENGRAF vs ORENCIA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. GENGRAF and ORENCIA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GENGRAF	ORENCIA
Rating	72/100	72/100
Pharmacy pays	~$52.85 /30	—
Type	RX	RX
Active ingredient	CYCLOSPORINE	ABATACEPT
Manufacturer	Abbvie	Bristol Myers Squibb
Dosage forms	Capsule	Injectable, Solution
Drug class	Calcineurin Inhibitor Immunosuppressant	—
Boxed warning	Boxed warning	None
Half-life	about 8.4 hours (range 5 to 18 hours)	—
Treats	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus	Juvenile Arthritis, Rheumatoid Arthritis, Psoriatic Arthritis

gengraf orencia

Rating

72/100

Pharmacy pays

~$52.85 /30

—

Type

Active ingredient

CYCLOSPORINE

ABATACEPT

Manufacturer

Abbvie

Bristol Myers Squibb

Dosage forms

Capsule

Injectable, Solution

Drug class

Calcineurin Inhibitor Immunosuppressant

—

Boxed warning

None

Half-life

about 8.4 hours (range 5 to 18 hours)

—

Treats

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Juvenile Arthritis, Rheumatoid Arthritis, Psoriatic Arthritis

Frequently asked questions

Which is better-rated, Gengraf or Orencia?

Gengraf and Orencia are tied at 3.6 out of 5 by our independent rating.

What is the difference between Gengraf and Orencia?

Gengraf contains Cyclosporine, while Orencia contains Abatacept — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.