FYARRO vs OFEV

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. FYARRO and OFEV are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FYARRO	OFEV
Rating	New	72/100
Pharmacy pays	~$48.61 /30	~$485.32 /30
Type	RX	RX
Active ingredient	SIROLIMUS	NINTEDANIB ESYLATE
Manufacturer	Aadi	Boehringer Ingelheim
Dosage forms	Injectable	Capsule
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Treats	Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms	Idiopathic Pulmonary Fibrosis

fyarro ofev

Rating

New

72/100

Pharmacy pays

~$48.61 /30

~$485.32 /30

Type

Active ingredient

SIROLIMUS

NINTEDANIB ESYLATE

Manufacturer

Aadi

Boehringer Ingelheim

Dosage forms

Injectable

Capsule

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms

Idiopathic Pulmonary Fibrosis

Frequently asked questions

Which is cheaper, Fyarro or Ofev?

Fyarro costs pharmacies less to acquire — about $48.61 vs $485.32 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Fyarro and Ofev?

Fyarro contains Sirolimus, while Ofev contains Nintedanib Esylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.