FOLOTYN vs OTREXUP

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. FOLOTYN and OTREXUP are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FOLOTYN	OTREXUP
Rating	New	New
Pharmacy pays	—	~$4.92 /30
Type	RX	RX
Active ingredient	PRALATREXATE	METHOTREXATE
Manufacturer	Acrotech Biopharma	Assertio Speclty
Dosage forms	Injectable	Injectable
Drug class	Folate Analog Metabolic Inhibitor	Folate Analog Metabolic Inhibitor
Boxed warning	None	Boxed warning
Half-life	—	about 3 to 10 hours
Treats	Peripheral T-Cell Lymphoma	Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

folotyn otrexup

Rating

New

Pharmacy pays

—

~$4.92 /30

Type

Active ingredient

PRALATREXATE

METHOTREXATE

Manufacturer

Acrotech Biopharma

Assertio Speclty

Dosage forms

Injectable

Drug class

Folate Analog Metabolic Inhibitor

Boxed warning

None

Boxed warning

Half-life

—

about 3 to 10 hours

Treats

Peripheral T-Cell Lymphoma

Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

Frequently asked questions

What is the difference between Folotyn and Otrexup?

Folotyn contains Pralatrexate, while Otrexup contains Methotrexate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.