FOLOTYN vs METHOTREXATE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. FOLOTYN and METHOTREXATE PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FOLOTYN	METHOTREXATE PRESERVATIVE FREE
Rating	New	54/100
Pharmacy pays	—	~$4.92 /30
Type	RX	RX
Active ingredient	PRALATREXATE	METHOTREXATE SODIUM
Manufacturer	Acrotech Biopharma	Hospira
Dosage forms	Injectable	Injectable
Drug class	Folate Analog Metabolic Inhibitor	Folate Analog Metabolic Inhibitor
Boxed warning	None	Boxed warning
Half-life	—	about 3 to 10 hours
Treats	Peripheral T-Cell Lymphoma	Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

folotyn methotrexate preservative free

Rating

New

54/100

Pharmacy pays

—

~$4.92 /30

Type

Active ingredient

PRALATREXATE

METHOTREXATE SODIUM

Manufacturer

Acrotech Biopharma

Hospira

Dosage forms

Injectable

Drug class

Folate Analog Metabolic Inhibitor

Boxed warning

None

Boxed warning

Half-life

—

about 3 to 10 hours

Treats

Peripheral T-Cell Lymphoma

Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

Frequently asked questions

What is the difference between Folotyn and Methotrexate Preservative Free?

Folotyn contains Pralatrexate, while Methotrexate Preservative Free contains Methotrexate Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.