FOCALIN XR vs VYVANSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. FOCALIN XR and VYVANSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FOCALIN XR	VYVANSE
Rating	68/100	New
Pharmacy pays	~$46.03 /30	—
Type	RX	RX
Active ingredient	DEXMETHYLPHENIDATE HYDROCHLORIDE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Sandoz	Takeda Pharms USA
Dosage forms	Capsule, extended release	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	—	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity	Attention Deficit Disorder with Hyperactivity, Binge Drinking

focalin xr vyvanse

Rating

68/100

New

Pharmacy pays

~$46.03 /30

—

Type

Active ingredient

DEXMETHYLPHENIDATE HYDROCHLORIDE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Sandoz

Takeda Pharms USA

Dosage forms

Capsule, extended release

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

—

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

What is the difference between Focalin XR and Vyvanse?

Focalin XR contains Dexmethylphenidate Hydrochloride, while Vyvanse contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.