FOCALIN XR vs RELEXXII

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. FOCALIN XR and RELEXXII are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FOCALIN XR	RELEXXII
Rating	68/100	70/100
Pharmacy pays	~$46.03 /30	~$18.94 /30
Type	RX	RX
Active ingredient	DEXMETHYLPHENIDATE HYDROCHLORIDE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Sandoz	Osmotica Pharm US
Dosage forms	Capsule, extended release	Tablet, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

focalin xr relexxii

Rating

68/100

70/100

Pharmacy pays

~$46.03 /30

~$18.94 /30

Type

Active ingredient

DEXMETHYLPHENIDATE HYDROCHLORIDE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Sandoz

Osmotica Pharm US

Dosage forms

Capsule, extended release

Tablet, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

—

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is better-rated, Focalin XR or Relexxii?

By our independent rating, Relexxii scores higher — 3.5 vs 3.4 out of 5 for Focalin XR. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Focalin XR or Relexxii?

Relexxii costs pharmacies less to acquire — about $18.94 vs $46.03 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Focalin XR and Relexxii?

Focalin XR contains Dexmethylphenidate Hydrochloride, while Relexxii contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.