FLUOXETINE HYDROCHLORIDE vs PAROXETINE MESYLATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. FLUOXETINE HYDROCHLORIDE and PAROXETINE MESYLATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FLUOXETINE HYDROCHLORIDE	PAROXETINE MESYLATE
Rating	New	70/100
Pharmacy pays	$0.05 /mL	~$2.84 /30
Type	RX	RX
Active ingredient	FLUOXETINE HYDROCHLORIDE	PAROXETINE MESYLATE
Manufacturer	Ph Health	Actavis Labs Fl Inc
Dosage forms	Capsule, Oral pellets, Solution, Tablet	Capsule
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	Boxed warning	None
Half-life	about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use	about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)
Treats	Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

fluoxetine hydrochloride paroxetine mesylate

Rating

New

70/100

Pharmacy pays

$0.05 /mL

~$2.84 /30

Type

Active ingredient

FLUOXETINE HYDROCHLORIDE

PAROXETINE MESYLATE

Manufacturer

Ph Health

Actavis Labs Fl Inc

Dosage forms

Capsule, Oral pellets, Solution, Tablet

Capsule

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Half-life

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)

Treats

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

What is the difference between Fluoxetine Hydrochloride and Paroxetine Mesylate?

Fluoxetine Hydrochloride contains Fluoxetine Hydrochloride, while Paroxetine Mesylate contains Paroxetine Mesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.