FLONASE vs SOLU-CORTEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. FLONASE and SOLU-CORTEF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FLONASE	SOLU-CORTEF
Rating	72/100	New
Pharmacy pays	—	$0.15 /g
Type	RX	RX
Active ingredient	FLUTICASONE PROPIONATE	HYDROCORTISONE SODIUM SUCCINATE
Manufacturer	Haleon US Holdings	Pharmacia and Upjohn
Dosage forms	Spray/Inhaler, metered	Injectable
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	—	about 1.5 hours
Treats	Perennial Allergic Rhinitis	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

flonase solu-cortef

Rating

72/100

New

Pharmacy pays

—

$0.15 /g

Type

Active ingredient

FLUTICASONE PROPIONATE

HYDROCORTISONE SODIUM SUCCINATE

Manufacturer

Haleon US Holdings

Pharmacia and Upjohn

Dosage forms

Spray/Inhaler, metered

Injectable

Drug class

Corticosteroid

Boxed warning

None

Half-life

—

about 1.5 hours

Treats

Perennial Allergic Rhinitis

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

What is the difference between Flonase and Solu-Cortef?

Flonase contains Fluticasone Propionate, while Solu-Cortef contains Hydrocortisone Sodium Succinate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.