FIORINAL W/CODEINE vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

Possible drug interaction. FIORINAL W/CODEINE and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FIORINAL W/CODEINE	MYSOLINE
Rating	72/100	74/100
Pharmacy pays	~$0.78 /30	~$2.89 /30
Type	RX	RX
Active ingredient	ASPIRIN AND BUTALBITAL AND CAFFEINE AND CODEINE PHOSPHATE	PRIMIDONE
Manufacturer	Allergan	Valeant Pharm Intl
Dosage forms	Capsule	Tablet
Drug class	—	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	about 20 minutes (the label also states 0.33 hours) for aspirin itself	—
Treats	—	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

fiorinal w/codeine mysoline

Rating

72/100

74/100

Pharmacy pays

~$0.78 /30

~$2.89 /30

Type

Active ingredient

ASPIRIN AND BUTALBITAL AND CAFFEINE AND CODEINE PHOSPHATE

PRIMIDONE

Manufacturer

Allergan

Valeant Pharm Intl

Dosage forms

Capsule

Tablet

Drug class

—

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 20 minutes (the label also states 0.33 hours) for aspirin itself

—

Treats

—

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Fiorinal W/Codeine or Mysoline?

By our independent rating, Mysoline scores higher — 3.7 vs 3.6 out of 5 for Fiorinal W/Codeine. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Fiorinal W/Codeine or Mysoline?

Fiorinal W/Codeine costs pharmacies less to acquire — about $0.78 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Fiorinal W/Codeine and Mysoline?

Fiorinal W/Codeine contains Aspirin and Butalbital and Caffeine and Codeine Phosphate, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.