FETZIMA vs TRINTELLIX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. FETZIMA and TRINTELLIX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FETZIMA	TRINTELLIX
Rating	72/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	LEVOMILNACIPRAN HYDROCHLORIDE	VORTIOXETINE HYDROBROMIDE
Manufacturer	Abbvie	Takeda Pharms USA
Dosage forms	Capsule, extended release, Kit	Tablet
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	—
Boxed warning	Boxed warning	Boxed warning
Half-life	about 12 hours	—
Treats	Major Depressive Disorder	Major Depressive Disorder

fetzima trintellix

Rating

72/100

New

Pharmacy pays

—

Type

Active ingredient

LEVOMILNACIPRAN HYDROCHLORIDE

VORTIOXETINE HYDROBROMIDE

Manufacturer

Abbvie

Takeda Pharms USA

Dosage forms

Capsule, extended release, Kit

Tablet

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

—

Boxed warning

Half-life

about 12 hours

—

Treats

Major Depressive Disorder

Frequently asked questions

What is the difference between Fetzima and Trintellix?

Fetzima contains Levomilnacipran Hydrochloride, while Trintellix contains Vortioxetine Hydrobromide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.