FETZIMA vs SAVELLA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. FETZIMA and SAVELLA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FETZIMA	SAVELLA
Rating	72/100	72/100
Pharmacy pays	—	~$97.10 /30
Type	RX	RX
Active ingredient	LEVOMILNACIPRAN HYDROCHLORIDE	MILNACIPRAN HYDROCHLORIDE
Manufacturer	Abbvie	Abbvie
Dosage forms	Capsule, extended release, Kit	Kit, Tablet
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	Serotonin and Norepinephrine Reuptake Inhibitor
Boxed warning	Boxed warning	Boxed warning
Half-life	about 12 hours	—
Treats	Major Depressive Disorder	Major Depressive Disorder

fetzima savella

Rating

72/100

Pharmacy pays

—

~$97.10 /30

Type

Active ingredient

LEVOMILNACIPRAN HYDROCHLORIDE

MILNACIPRAN HYDROCHLORIDE

Manufacturer

Abbvie

Dosage forms

Capsule, extended release, Kit

Kit, Tablet

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

Boxed warning

Half-life

about 12 hours

—

Treats

Major Depressive Disorder

Frequently asked questions

Which is better-rated, Fetzima or Savella?

Fetzima and Savella are tied at 3.6 out of 5 by our independent rating.

What is the difference between Fetzima and Savella?

Fetzima contains Levomilnacipran Hydrochloride, while Savella contains Milnacipran Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.