FENTANYL CITRATE vs ULTRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. FENTANYL CITRATE and ULTRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FENTANYL CITRATE	ULTRAM
Rating	68/100	70/100
Pharmacy pays	$9.51 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	FENTANYL CITRATE	TRAMADOL HYDROCHLORIDE
Manufacturer	Fresenius Kabi USA	Janssen Pharms
Dosage forms	Injectable	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	—	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Pain	Pain

fentanyl citrate ultram

Rating

68/100

70/100

Pharmacy pays

$9.51 /mL

~$0.72 /30

Type

Active ingredient

FENTANYL CITRATE

TRAMADOL HYDROCHLORIDE

Manufacturer

Fresenius Kabi USA

Janssen Pharms

Dosage forms

Injectable

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Pain

Frequently asked questions

Which is better-rated, Fentanyl Citrate or Ultram?

By our independent rating, Ultram scores higher — 3.5 vs 3.4 out of 5 for Fentanyl Citrate. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Fentanyl Citrate and Ultram?

Fentanyl Citrate contains Fentanyl Citrate, while Ultram contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.