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FENTANYL CITRATE vs LOPERAMIDE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. FENTANYL CITRATE and LOPERAMIDE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
70/100

Pharmacy pays

$9.51 /mL
$0.05 /mL

Type

RX
RX

Active ingredient

FENTANYL CITRATE
LOPERAMIDE HYDROCHLORIDE

Dosage forms

Injectable
Capsule

Drug class

Opioid Agonist
Opioid Agonist

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

Treats

Pain
Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Frequently asked questions

Which is better-rated, Fentanyl Citrate or Loperamide Hydrochloride?

By our independent rating, Loperamide Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Fentanyl Citrate. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Fentanyl Citrate or Loperamide Hydrochloride?

Loperamide Hydrochloride costs pharmacies less to acquire — about $0.05 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Fentanyl Citrate and Loperamide Hydrochloride?

Fentanyl Citrate contains Fentanyl Citrate, while Loperamide Hydrochloride contains Loperamide Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.