FENTANYL-100 vs HYDROMORPHONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. FENTANYL-100 and HYDROMORPHONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FENTANYL-100	HYDROMORPHONE HYDROCHLORIDE
Rating	New	44/100
Pharmacy pays	$9.51 /mL	$0.57 /mL
Type	RX	RX
Active ingredient	FENTANYL	HYDROMORPHONE HYDROCHLORIDE
Manufacturer	Mylan Technologies	Hospira
Dosage forms	Patch	Suppository, Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
Treats	Pain	Cough, Postoperative Pain

fentanyl-100 hydromorphone hydrochloride

Rating

New

44/100

Pharmacy pays

$9.51 /mL

$0.57 /mL

Type

Active ingredient

FENTANYL

HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Mylan Technologies

Hospira

Dosage forms

Patch

Suppository, Tablet

Drug class

Opioid Agonist

Boxed warning

Half-life

—

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Pain

Cough, Postoperative Pain

Frequently asked questions

Which is cheaper, Fentanyl-100 or Hydromorphone Hydrochloride?

Hydromorphone Hydrochloride costs pharmacies less to acquire — about $0.57 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Fentanyl-100 and Hydromorphone Hydrochloride?

Fentanyl-100 contains Fentanyl, while Hydromorphone Hydrochloride contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.