FEMSTAT vs TOLSURA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. FEMSTAT and TOLSURA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FEMSTAT	TOLSURA
Rating	New	70/100
Pharmacy pays	—	$0.84 /mL
Type	RX	RX
Active ingredient	BUTOCONAZOLE NITRATE	ITRACONAZOLE
Manufacturer	Roche Palo	Mayne Pharma
Dosage forms	Suppository, Topical	Capsule
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	Boxed warning
Half-life	—	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.
Treats	Vulvovaginal Candidiasis	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

femstat tolsura

Rating

New

70/100

Pharmacy pays

—

$0.84 /mL

Type

Active ingredient

BUTOCONAZOLE NITRATE

ITRACONAZOLE

Manufacturer

Roche Palo

Mayne Pharma

Dosage forms

Suppository, Topical

Capsule

Drug class

Azole Antifungal

Boxed warning

None

Boxed warning

Half-life

—

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

Treats

Vulvovaginal Candidiasis

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

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Frequently asked questions

What is the difference between Femstat and Tolsura?

Femstat contains Butoconazole Nitrate, while Tolsura contains Itraconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.