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EXPAREL vs XARACOLL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. EXPAREL and XARACOLL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

exparelxaracoll

Rating

70/100
New

Pharmacy pays

$0.06 /mL
$0.06 /mL

Type

RX
RX

Active ingredient

BUPIVACAINE
BUPIVACAINE HYDROCHLORIDE

Manufacturer

Pacira Pharms Inc
Innocoll

Dosage forms

Injectable, Liposomal
Implant

Drug class

Amide Local Anesthetic
Amide Local Anesthetic

Boxed warning

None
None

Treats

Postoperative Pain
Postoperative Pain

Frequently asked questions

Which is cheaper, Exparel or Xaracoll?

Pharmacies pay about the same to acquire either one — roughly $0.06 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Exparel and Xaracoll?

Exparel contains Bupivacaine, while Xaracoll contains Bupivacaine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.