EXEMESTANE vs LETROZOLE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. EXEMESTANE and LETROZOLE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EXEMESTANE	LETROZOLE
Rating	72/100	72/100
Pharmacy pays	~$18.36 /30	~$4.50 /30
Type	RX	RX
Active ingredient	EXEMESTANE	LETROZOLE
Manufacturer	Rising	Hikma
Dosage forms	Tablet	Tablet
Drug class	Aromatase Inhibitor	Aromatase Inhibitor
Boxed warning	None	None
Half-life	—	about 2 days (terminal elimination half-life)
Treats	Breast Neoplasms	Breast Neoplasms

exemestane letrozole

Rating

72/100

Pharmacy pays

~$18.36 /30

~$4.50 /30

Type

Active ingredient

EXEMESTANE

LETROZOLE

Manufacturer

Rising

Hikma

Dosage forms

Tablet

Drug class

Aromatase Inhibitor

Boxed warning

None

Half-life

—

about 2 days (terminal elimination half-life)

Treats

Breast Neoplasms

Frequently asked questions

Which is better-rated, Exemestane or Letrozole?

Exemestane and Letrozole are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Exemestane or Letrozole?

Letrozole costs pharmacies less to acquire — about $4.50 vs $18.36 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Exemestane and Letrozole?

Exemestane contains Exemestane, while Letrozole contains Letrozole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.